KINE 1020 : Lecture Notes Semester 2.docx

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Lowers risk of functional limitations: prevents injury and infirmity, is a predictor of advanced age disability, reduced chronic low back pain. Lowers risk of chronic diseases: improved blood sugar control, slows/prevents osteoporosis, increases metabolic rate. May help individuals to fill job/occupational requirements : reduces risk of injury/increases productivity. Sarcopenia is the loss of muscle mass and strength due to the aging process. Involves apoptosis a decreased number of muscle fibres/mass/strength. Sarcopenia is a result of programmed cell death which is characterized by: Dna fragmentation (dna falls apart: caused by a protein called dna fragmentation factor (dff) 40, under normal circumstances dff45 is present instead, which inhibits dff40 preventing the degradation it causes. If dff45 is damaged/altered, dff40 can become active: influenced by caspase-3 protease that breaks down dff45 (more of this = active dff40 = more fragmentation) Nuclear condensation (nucleus dissolves) occurs in stages: influenced by apoptosis-inducing factor (aif)

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