KINE 4010 Midterm: KINE 4010 Midterm 2
6 Nov 2013
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More h-ldh means higher lactate threshold, more st fibres increase la threshold: st increase la threshold because have more mitochondria than ft and they have. Take body up to high altitude will shift the threshold acutely lower b/c oxygen delivery is lower- exposure to environment- like climbing killimanjaro. Gene expression is the turning on or off of genes depending on environment/adaptations. With exercise we can have h-ldh increase and m-ldh decrease. Tf- transcription factors- proteins that accelerate or decelerate transcription: tf1 bind to rna polymerase to increase h-ldh in response to exercise, tf2 decrease m-ldh. If the protein is a transcription factor, it can enter the nucleus and affect the transcription of a gene. The synthesis of more protein, or of different proteins, via this mechanism leads to muscle adaptations. Adaptations occur with activation or reduction of certain genes. Lots of people studying how muscles adapt and about gene expression.
