NATS 1670 Study Guide - Final Guide: Immunoglobulin G
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Degranulation of many mast cells @ once causes the release of large amounts of histamine and
Can result in acute anaphylaxis or anaphylactic shock
Treatment of anaphylactic shock
Anaphylactic shock is an especially dangerous type of llergic reaction
Requires emergence medical care ASAP!!
Can be counteracted (temporarily) with injections of epinephrine which neutralizes many of the
mechanisms of anaphylaxis, relaxes smooth muscles and reduces vascular permeability. This
provides time to get the emergency medical help the patient needs
Treatments for Allergy
Identify the allergen
Avoid the allergen
Drugs- Antihistamines neutralize histamine, asthma can be treated with an inhalant containing
corticosteroid and a bronchodilator
Immunotherapy- Desensitization (Induce IgG instead of IgE)
Principles of Immunotherapy
Is a form of treatment to reduce the allergic reaction
Consists of a series of injections with a solution containing the allergen that causes the allergic
Decreases the sensitivity to the allergens
Facts about the relationship between clean environment and allergy: Lower incidence of allergy
in those living in rural areas. Lower incidence of allergy in the younger children of large families.
Lower incidence of asthma in children who go to day care. In conclusion exposure to more
antigens at younger age= Less allergy (Hygiene hypothesis)
A hypothesis that states that exposure to allergens in the environment early in life reduces the
risk of developing allergies by boosting immune system activity
Conversely, relatively clean environment in early life would push the immune system towards
allergy promoting responses.