NATS 1670 Study Guide - Final Guide: Cell Surface Receptor, Passive Immunity, Drug Resistance
14 Jan 2015
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Host range: host range may be wide or narrow. Only one species (ex: smallpox only affecting humans) Animals, insects and humans (ex: west nile virus) Zoonotic viruses: zoonotic viruses pursue their biologic cycles chiefly in animals. Humans are secondary or accidental hosts (ex: human travelling in jungle: these viruses are limited to areas and environments able to support their nonhuman natural cycles of infection. Factors affecting host range: cell surface receptor, availability of replication machinery, ability to get out of the cell and spread, host anti-viral response. These factors also dictate the type of cell and tissue infected, thus potentially leading to disease. Infection by the rabies virus: uptake, the axon is transported and replicated, the virus must survive the transsynaptic spread in order to continue if successful, it continues to replicate. Prevention (ex: removing buckets of water to avoid mosquitos) In order to control viral disease: we need to know about the virus.
