BIOL2000 Study Guide - Midterm Guide: Chemotherapy, T Helper Cell, Ivermectin
Document Summary
Blackflies (larvae live in fast flowing oxygen rich water) Infection occur in proximity to fast moving water. Adult worms form nodules in cutis enclosed by host w/ fibrotic granuloma (onchocercoma) Microfilaria migrate through connective tissue and cause most of pathology once they die, enlisting inflammatory response (th2 response) Scratching = skin hardening and loss of pigment. Microfilaria also migrate through eye, once die and inflammation can lead to scarring of cornea (sclerozing ceratitis) Cornea becomes opaque = gradual loss of vision. L1 larvae swept into bloodstream and circulate, remain infective for several months. Diurnal rhythm, found in blood during night (increase chance to take up by vector?) L1 (mf) taken up by mosquito and leave sheath in midgut, and migrate to flight muscle where they molt twice. L3 migrate through hemolymph until find labium, which penetrate when sense feeding and move into wound. Females produce l1 larvae still in egg membrane (sheath)
