BIOL 1260 Midterm: Drugs to know for midterm 2
2 Dec 2016
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In form of dimers/hexamers in solution, slow diffusion across membrane. Insulin in monomer form rather than hexamer form. Soluble at low ph, precipitates at neutral/subcutaneous ph. Activates ampk which inhibits transcription of proteins involved in creating/releasing glucose. Block k+ channels influx of ca2+ increase in insulin release. Activate ppar-gamma (high in adipose) stimulates ampk phosphorylation increases glucose uptake a-glucosidase inhibitors diabetes slow glucose absorption in gi tract. Exenatide diabetes acts centrally to suppress inappropriate post-meal glucagon surge. Dpp-4 inhibitor very similar to glp-1 (synthetic analog of lizard spit) prodrugs that are metabolized into estradiol decreased progestin dose. Depo provera (medroxyprogestero prophylactic contraceptive contraceptive progestin injection of dmpa ne acetate) Norgestrel prophylactic contraceptive progestin pill, mix of 2 isomers (only one is. Competitively inhibit alpha-glucosidase enzymes delays breakdown of sugars. Analog of amylin, which is coreleased with insulin. Gl-1p (released with food ingestion, helps control glucose levels) Binds to glp-1 receptors and is resistant to dpp-4.
