BIOS 15115 Study Guide - Midterm Guide: Metastasis, Platelet-Derived Growth Factor, Micrometastasis
7 Sep 2016
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Rb protein a 105 kda protein, which depends on cyclins and cyclin kinases for activation and inactivation. It is activated when hypophosphorylated and controls the passage through the r point. p15ink this inhibits cyclin d and the cdk 4/6 complex that dephosphorylates the. Bcl-2 a survival factor that enables cells to evade apoptosis by blocking the release of cyctochrome c (by binding to the pore-making bak and bax). It can be inhibited by bim and bid p53 53 kda protein which is mutated in about 50% of all tumors. It drives cells towards apoptosis and acts as a transcription factor. In moderate stress it leads to growth arrest and repair. Telomerase enzyme that extends the telomeres of cells dna. Caspases proteases that are the effectors of apoptosis. Taf (tumor angiogenesis factor) must be released to induce vascularization. When it binds to vegfr, this leads to proliferation (plc-gamma pathway), migration (grb2 pathway) and cell survival.
