Sexual differentiation, development of external genitalia, disorders of sex development, sex steroid hormones, testes, cryptorchidism

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Department
Biomedical Science
Course
BMS 360
Professor
Douglas Ishii
Semester
Spring

Description
9 AprilSexual DifferentiationSecondary Sex DeterminationAlfred Jost SummaryExp 1 remove gonadsXX and XYMullerian ductsExp 2 remove gonadstestosteroneXX and XYWolffianMullerian ductsExp 3 remove gonads of XXtestis fragmentXXWolffian ductsPhenotypic sexRequire testosteroneAMH to form Wolffian ducts and degenerate Mullerian ductAMHanti Mullerian hormoneDevelopment of External GenitaliaStarts the sameUrethral foldurethral groove within foldFold fusesgroove disappears in maleRemains separate in femaleGenital tubercle forms penis or clitorisDevelopment of Male External GenitaliaTestosterone5reductasedihydrotestosterone DHTMore potent
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