BISC 2213- Midterm Exam Guide - Comprehensive Notes for the exam ( 15 pages long!)
Document Summary
Study guide: positive correlation between being old and mortality/morbidity, by age 60, there is a higher incidence of cancer. Lecture 6- age and cancer: as one gets older, a. ) Strong mitogenic stress- as one gets older, they will become exposed to factors that will cause cell proliferation. Hormones and growth factors (ras, e2f: c. ) cell proliferation & shortening of telomerase, d. ) oncogenic expression. Individual cells seem to have a built-in limit on the number of cell divisions. Each cell stops dividing after 50-60 divisions and enters senescence (excluding brain cells: senescence non-proliferative state still viable but don"t divide; brought on by cellular stress. A normal cell contains a total of 4 telomeres per chromosome and a size of 12kb. The first part where a cell becomes cancerous occurs in bfb in situ cancer (treatable if detected early) Bfb is directly involved in genomic instability. There is not one thing, but multiple factors that contribute to turning on telomerase.
