BIO 447 Study Guide - Final Guide: Pinocytosis, Endocytosis, Stromal Cell-Derived Factor 1
Document Summary
Destroy bacteria and fungi first responders to microbial infection: die after phagocytizing few pathogens (short-lived, hours/days) Bone marrow releases more neutrophils during infection leukocytosis. Responds to chemotactic factors released by infection/inflammation (e. g. from complement or blood-clotting reactions, or cytokines released by t- cells/macrophages) Granules release antimicrobial agents fuse with phagosomes for digestion/eliminated. Primary granules larger, denser = peroxidase, lysozyme, hydrolases. Secondary granules smaller = proteases, collagenase, lactoferrin. Neutrophils trails guide virus-specific cd8+ t cell migration. 50% of circulating leukocytes multi-lobed nucleus, granulated cytoplasm. Granules in cytoplasm - vesicles w/ chemicals released by exocytosis. In the influenza-infected trachea, tissue-infiltrating neutrophils (pink) deposit chemokine (cxcl12) containing trails. Long-lasting chemokine depots provide both chemotactic and haptotactic cues for virus- specific cd8+ t cell migration and localization in the infected tissues. Bilobed nucleus, granulated cytoplasm stains with acid. Targets multicellular parasites (intestinal worms: acidic granules - secrete toxic proteins, free radicals, release cationic proteins, ribonucleases, cytokines, chemokines. Bilobed nucleus, super-granulated cytoplasm stains with base.
