BIOL 4376 Study Guide - Final Guide: Blood Sugar, Reference Range, Liver Disease

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Published on 29 Jul 2020
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(PO4-), and H+ is excreted
Collecting duct
Regulates amount of H2O in urine as a result of antidiuretic hormone (ADH),
which facilitates H2O reabsorption
I.e. dehydration, collecting duct reabsorbs more water to help urine
concentration
Endogenous Markers
Serum Creatinine (Scr) - the worse the kidney function, the higher the Scr excreted at a relatively
constant rate
Description
Made from metabolism of creatinine in skeletal muscle and dietary meat intake
Released into circulation at a constant rate
Freely filtered across glomerulus and excreted by kidneys; neither reabsorbed nor
metabolized by kidney
Primary role
Most important endogenous biomarker used for detection of kidney disease
Reference range
0.5-1.5 mg/dL
Abnormal levels
Increased Scr commonly caused by renal dysfunction (or increased protein diet)
Decreased SCR commonly caused by decrease in muscle mass (i.e. elderly,
malnutrition)
Not associated with kidney dysfunction
Blood Urea Nitrogen (BUN) - acute kidney injury (AKI)
Description: test that measures amount of urea in blood
Protein metabolism → amino acids metabolized to ammonia → converted to
urea in liver
Filtered and excreted by kidneys; about 40-50% of filtered urea is passively
absorbed (mostly in proximal tubule)
Rate of urea production is not constant:
Increased with renal dysfunction (urea can’t be secreted out if your
kidneys are dysfunctional); also high protein diet, enhanced tissue
breakdown from hemorrhage, trauma
Decreased with low-protein diet, liver disease
Thus cannot be used by itself to assess renal function
Reference range:
8-18 mg/dL
BUN:Scr Ratio
Useful tool when categorizing acute kidney injury (AKI)
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Document Summary

Regulates amount of h2o in urine as a result of antidiuretic hormone (adh), which facilitates h2o reabsorption. I. e. dehydration, collecting duct reabsorbs more water to help urine concentration. Serum creatinine (scr) - the worse the kidney function, the higher the scr excreted at a relatively constant rate. Made from metabolism of creatinine in skeletal muscle and dietary meat intake. Released into circulation at a constant rate. Freely filtered across glomerulus and excreted by kidneys; neither reabsorbed nor. Most important endogenous biomarker used for detection of kidney disease metabolized by kidney. Increased scr commonly caused by renal dysfunction (or increased protein diet) Decreased scr commonly caused by decrease in muscle mass (i. e. elderly, malnutrition) Blood urea nitrogen (bun) - acute kidney injury (aki) Description: test that measures amount of urea in blood. Protein metabolism amino acids metabolized to ammonia converted to urea in liver. Filtered and excreted by kidneys; about 40-50% of filtered urea is passively absorbed (mostly in proximal tubule)

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