BIO 253 Study Guide - Quiz Guide: Covalent Bond, Organelle, Centrifugation

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lavendergiraffe572

23 Feb 2017

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University of Rochester

Department

Biology

Course

BIO 253

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Document Summary

Know all the phi and psi angles of each amino acid in a change of alanine amino acids. For ramachandran plots, you plot the angles of psi and phi and you see that the angles of an amino acid usually groups and have common angles that they have. Now you can take an unknown structure of a protein and take an alanine, then it will most likely have that angles. Histidine can be affected very easily because it has a pka of 6 so can be easily protonated or deprotonated from physiologically ph. The adult has alpha beta alpha beta tetramer for hemoglobin. However, when you are a fetus, you have alpha gamma alpha gamma because. Hemoglobin and cause it to be in the t state and therefore less bpg. = more r state and more higher affinity for oxygen and more oxygen for the baby.

Related Questions

1. Amino acid changes in the primary structure of the protein arenot capable of causing changes in the
overall shape of a protein.
a.) True
b.) False

2. An alpha helix:
a.) is destabilized by the amino acid alanine
b.) can only form by hydrogen bonding between different polypeptidechains
c.) can only form when cysteines form disulfide bridges within thisstructure
d.) all of the above
e.) none of the above

3. What will likely happen if two aspartates at pH 5 are next toeach other in a polypeptide chain?
a.) The side chains of these amino acids will be uncharged andthere will be no effect.
b.) The side chains of these amino acids will be charged and theywill attract each other.
c.) The side chains of these amino acids will be charged and theywill repel each other.
d.) Not enough information is given to determine the effect.

4. Consider the amino acid phenylalanine. Which of the followingbest describes where you predict this
amino acid would be found?
a.) This amino acid is hydrophobic and would be on the surface of aprotein that is in the middle
of a membrane.
b.) This amino acid is hydrophilic and would be on the surface of aprotein that is in the middle
of a membrane.
c.) This amino acid is hydrophobic and would be in the interior ofa protein that is in the middle
of a membrane.
d.) This amino acid is hydrophilic and would be in the interior ofa protein that is in the middle of
a membrane.
e.) Not enough information is given to determine.

5. The difference between fetal and adult hemoglobin with regard tooxygen binding occurs because fetal
hemoglobin has an amino acid substitution in one of its chains thatresults in a histidine being replaced by a
serine.
a.) True
b.) False

1. The side chain of tyrosine is considered to be polar because even though it is reminiscent of phenylalanine it also has two types of atoms that have large differences in electronegativity with asymmetry at the terminus.

a.) True

b.) False

2. Which of these changes in primary structure will be certain to cause a loss of protein activity?

a.) Asp to Glu

b.) His to Lys

c.) Trp to Ser

d.) Gly to Pro

e.) Not enough information is given since any one of these changes could be severe depending on the context of the situation

3.The difference between fetal and adult hemoglobin with regard to oxygen binding occurs because fetal hemoglobin has an amino acid substitution in one of its chains that results in a histidine (adult version) being replaced by a serine (fetal version).

a.) True

b.) False

4. What will likely happen if the side chains of aspartate and histidine at pH 5 are next to each other in a polypeptide chain?

a.) The side chains of these amino acids will be uncharged and there will be no electrostatic effect.

b.) The side chains of these amino acids will be charged and they will attract each other.

c.) The side chains of these amino acids will be charged and they will repel each other.

d.) Not enough information is given to determine the effect.

5. A beta pleated sheet:

a.) can occur between two different polypeptide chains
b.) can be formed by either intramolecular or intermolecular hydrogen bonds
c.) can only form when cysteines form disulfide bridges within this structure
d.) forms when side chains of D and E attract each other
e.) both a and b

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BIO 253 Study Guide - Quiz Guide: Covalent Bond, Organelle, Centrifugation

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