MICROM 442 Study Guide - Final Guide: Pertussis Toxin, Lymphocyte, Respiratory Epithelium
Document Summary
4:13 pm: bordatella pertussis is a gram negative coccobacillus that specifically colonizes and destroys ciliated epithelium of large airways, virulence factors: Filamentous haemagluttinin (fha) (adhesins with pro- apoptotic and proinflammatory activity in host cells) and pili for attachment. Tracheal cytotoxin: toxin peptidoglycan (pg) fragment destroys ciliated cells via no and il-1 pathway. It introduced no into the respiratory epithelium and inhibits an enzyme aconitase of the cells. By interfering with the il-1 pathway it inhibits the production of interleukins, which decreases the immune response. Pertussis toxin: ab subunit toxin that causes the transfer of. Adp ribose to the alpha subunit on heterotrimeric proteins. This leads to the inhibition of g-protein coupled receptors and an increase in camp. This alters leukocyte homing and function, and causes lymphocytosis, which is a high lymphocyte count. Adenylate cyclase toxin: catalyzes atp--> camp, also hemolysin. Fha, pt, and act expression is controlled by two-
