CHEM 153C Study Guide - Final Guide: Acid Dissociation Constant, Dirham, Catabolism
22 Jun 2016
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Document Summary
The formation of a fatty acyl-amp (acyladenylate) is the first step in the activation of fatty acids for oxidation. => pyrophosphatase rapidly removes ppi, thus lowering the concentration of this product of the reaction, thus insuring the thermodynamic favorability. Four reaction types (e. g. oxidation) involved in fatty acid oxidation: dehydrogenation (oxidation) 2. Failure to coordinate glucose and fat metabolism due to acyl-coa deficiency, one may possibly fail to produce adequate atp for processes necessary for survival when blood glucose is low. Problems of unsaturated fa: (a) not a substrate for and inhibits enoyl hydratase. (b) 2-enoyl-coa (c) 3-enoyl-coa (d) isomerization to 2-enoyl-coa. Malic enzyme oxidizes the malate to oxaloacetate and decarboxylates the oxaloacetate to pyruvate. Pyruvate is decarboxylated to acetyl-coa by pyruvate dehydrogenase. This enzyme oxidatively decarboxylates cytoplasmic malate to pyruvate that can be completely oxidized by pyruvate dehydrogenase and the citric acid cycle. Aspartate shuttle transports malate produced in the mitochondrial from succinyl-coa to the cytoplasm. ]
