NURS 3110 Study Guide - Quiz Guide: Tolnaftate, Posaconazole, Terbinafine
Document Summary
Crytococcus species that don"t respond to amphotericin b deoxycholate. Relapse rates common in immunocompromised pts with visceral leishmaniais. Infusion rxn: pretreat with triad of drugs (acetaminophen, antihistamine, antiemetic) Phlebitis: pretreat with heparin, changes sites, use lg central vein. Moa: interfere with fungal dns synthesis, bind to fungal cell membrane ergosterol leak. Candidiasis mucous membranes, moist skin (dermatophytes skin, hair, nails) Many drug interactions: decrease ergosterol synthesis, inhibit cell membrane formation. Invasive aspergillosis and mucormycosis (life- threatening fungal infections in immunocompromised) Drugs that effect gastric ph (ppis, antacids, h2 receptor antagonist) Interferes with cytochrome p450 activity, decreasing erogosterol synthesis, inhibit cell membrane formation. Wheezing, chest tightness, fever, itching, bad cough, cyanosis, seizures, swelling of face, Can use suppositories even on period, do not use tampons. Oropharyngeal candidiasis (suspension only) tongues, lip, throat, tongue. 1st topical azole antifungal agent for tinea cruris and tinea corporis, 1 week. Toenail onychomycosis caused by trichophyton rubrum or trichophyton mentagrophytes.
