BISC401 Study Guide - Midterm Guide: Atp Hydrolysis, Dephosphorylation, Histone Methyltransferase

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Different genes can be created by exon duplication via recombination. Homologous noncoding sequences called l1 long interspersed ele(cid:373)e(cid:374)ts lie 5" a(cid:374)d (cid:1007)" of the gene and between exons 2 and 3. Homologous recombination between the two parental chromosomes generate one recombinant chromosomes: gene 1 now has 4 copies of exon instead of three (two copies of exon 3, gene 2 is missing 1 exon (exon 3) Unequal crossing due to repetitive dna is involved in gene duplication. Ea(cid:272)h pa(cid:396)e(cid:374)tal (cid:272)h(cid:396)o(cid:373)oso(cid:373)e (cid:272)o(cid:374)tai(cid:374)s o(cid:374)e a(cid:374)(cid:272)est(cid:396)al -globin gene. Unequal recombination between l1 elements and subsequent independent mutations yield duplicated genes on one chromosome that might encode slightly different proteins. Repetitive dna is involved in (cid:862)e(cid:454)o(cid:374) shuffli(cid:374)g(cid:863) by enabling gain or loss of exons. A double crossover recombination between two sets of alu repeats result in an exchange of exons between two genes. The (cid:374)u(cid:373)(cid:271)e(cid:396) of p(cid:396)otei(cid:374) (cid:272)odi(cid:374)g ge(cid:374)es i(cid:374) a(cid:374) o(cid:396)ga(cid:374)is(cid:373)"s ge(cid:374)o(cid:373)e is not directly related to its biological complexity.

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