NSCI634 Study Guide - Midterm Guide: Dorsal Raphe Nucleus, G Protein–Coupled Receptor, Posttraumatic Stress Disorder

• School: University of Delaware
• Department: Neuroscience
• Course: NSCI634
• Professor: Tania Roth

Document Summary

Crf (aka crh) is a major regulator of our responses to internal and external stressors. Other key players include: urocortin 1, urocortin 2, urocortin 3, crf1, crf2. Crf: a hypothalamic factor; produces cells throughout the cns. Ucn1: can stimulate production of acth; administration produces mildly behavioral arousing properties and anxiogenic-like effect. Ucn2 and ucn3 administration does not increase cort secretion. The biological actions of crf and ucn are mediated via two types of g protein coupled receptors: crf1 and crf2. Ucn2 and ucn3 are selective activators of crf2. Crf receptors affect your stress response, anxiety, depression. Crf1 is more widely distributed in the brain. Crf2 is located in more discrete brain regions. The behavioral effects of crf are mediated in part by its actions on serotonergic systems, suggesting the intersection of crf pathways with 5-ht neurotransmission is a likely way stress influences mood. Electrophysiological, biochemical, and anatomical studies have shown direct crf input to dorsal raphe nucleus.