MCDB 310 Study Guide - Midterm Guide: Pyruvate Dehydrogenase, Lactate Dehydrogenase, Alcohol Dehydrogenase

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Mcdb 310 exam 3 need to know guide: note the four pathways of glucose utilization, which are called fates (figure 14-1), glucose can be oxidized to pyruvate through glycolysis. One molecule of glucose produces two molecules of pyruvate. Glycogen is the storage form of glucose in animals. Starch is the storage form of glucose in plants and sucrose is the transport form of glucose in plants. It is strongly favored to go to lactate, but is still reversible: proceeds under anaerobic conditions, ethanolic fermentation, only in yeast, 2 steps, first, pyruvate is converted to acetaldehyde using pyruvate decarboxylase. This reaction requires tpp and mg2+ as cofactors and releases co2. The second step uses alcohol dehydrogenase the addition of nadh + h+ to produce nad+ and ethanol. Under aerobic conditions, pyruvate will be made into acetyl-coa to proceed to the citric acid cycle. Under anaerobic conditions, pyruvate can undergo fermentation, either lactic acid fermentation or alcohol fermentation.

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