NURSE-3111 Study Guide - Midterm Guide: Amphotericin B, Hemoglobin, Thrombin
Document Summary
Chapter 83 general principles of antimicrobial therapy. The term selective toxicity is defined as the ability of a drug to injure a target cell or target organism without injuring other cells or organisms that are in intimate contact with the target. Inhibition of an enzyme unique to bacteria. Paba folic acid precursor they can"t make their own if we block paba. Their ribosomes are different than ours so we can interfere with their protein synthesis. Broad spectrum antibiotics before culture/sensitivity results are back. When should cultures be obtained: prior to the initiation of tx- if antibiotics are present in the sample it can suppress microbial growth in the culture and confound identification. What are some common ones: diarrhea- c. diff, yeast infections. Indications for combination therapy: initial therapy of severe infection. The most common indication for using multiple antibiotics is initial therapy of severe infection of unknown etiology, especially the neutropenic host: mixed infections.
