NRS 313 Study Guide - Midterm Guide: Leukocyte Extravasation, Angiogenesis, B Cell
27 May 2018
School
Department
Course
Professor
W2: Biodefense: Inflammatory response and adaptive immunity
• Infection
o Acidosis: pH< 7.35
o Decreased blood volume
o Vascular volume decreases
o Fever fro acidic environment
o Blowing off CO2 and bringing in O2
o Long cap refill
o Not many bowel sounds
• Three levels of protection
o Innate (natural) and non-specific
▪ 1. Physical/ Chemical: Skin and moucous membranes prevent antigens
from netering our bodies
▪ 2. Inflammatory: Antigen detection. Mast cells
o Adaptive (acquired)
▪ 3. Acquired Immunity – specific antibodies produced for specific antigen
(virus and bacteria): How you build immunity= lymphocytes. Create
antibodies
• Inflammatory Response – Acute( time limited)
o First immediate response to an injury/antigen – the response is the SAME in all
tissues.
o Overall goal: remove the injurious agent and limit tissue damage
o Acute Response: lasts 8 – 10 days
o Mast Cells release platelet activated factor produced by Mast cells and travels to
the liver. They tell the liver to release clotting factor = Fibrogen.
• Inflammatory response – chronic
o Persistent inflammatory activity can lead to permanent cellular damage
o Chronic macrophage activity leads to fibrosis of affected tissue and organs.
▪ Exemplar:
• Chronic reactive airway disease – fibrotic scarring and narrowing
of upper airways
• Chronic inflammation = chronic acidosis= Cancer
• Chronic macrophage activity and swelling causes remodeling and
scar tissue in bronchial tubes. Leads to restriction in airway
movements
o Any chronic inflammatory process will result in modifying in the structure of the
tissue
o When activated, two processes begin:
▪ Degranulation, releasing substances into ECF
• to help heal the body
• Burst cytokins to help heal
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Infection: acidosis: ph< 7. 35, decreased blood volume, vascular volume decreases, fever fro acidic environment, blowing off co2 and bringing in o2, long cap refill, not many bowel sounds, three levels of protection, innate (natural) and non-specific, 1. Physical/ chemical: skin and moucous membranes prevent antigens from netering our bodies: 2. Acquired immunity specific antibodies produced for specific antigen (virus and bacteria): how you build immunity= lymphocytes. They tell the liver to release clotting factor = fibrogen. Why we get inflammation: degranualtion, chemotactic factors, neutrophils, eosinophils, histamine, synthesis, platelet activating factor, arachodonic acid, leukotionenes, prostoglandins. Make up about 60 70% of white blood cells: enter the area in about 90 minutes post-injury. Crp is an opsonin. (pg: fibrinogen part of the clotting cascade. Increases: erythrocyte sedimentation rate (esr) - rate at which rbcs sediment(how fast the. Rbc falls) in a period of one hour; increases in response to inflammation.
