L07 Chem 481 Study Guide - Final Guide: Acetylcholine, Tomm22, Transcription Activator-Like Effector Nuclease
13 Dec 2016
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Proofreading activity, extension of okazaki fragments (fills gap between fragments/primer) Pol is anchored in front of helicase ( subunit displaces primase and moves clamp) Linked to back of helicase via a bridging factor. Rnase h removes rna nucleotides up to last. Forms clamp (3 , 1 , 1 -5-oh overhang. Facilitates strand invasion, binds ssdna, facilitates homologous pairing to form holliday junction. Right handed helical filament, 6 monomers/turn, fits 3 dna strands, forms. Hexamer that works as a aaa+atpase motor with. Spins dna to integrate strands and facilitate exchange. A dimer endonuclease that resolves the holliday junction into heteroduplex products.
