CHEM 271 Chapter Notes - Chapter 16: Adenylate Kinase, Phosphofructokinase, Hexokinase

• School: Concordia University
• Department: Chemistry
• Course: CHEM 271
• Professor: Lena Sahlman

Document Summary

16. 2 the glycolytic pathway is tightly controlled (regulation of glycolysis powerpoint) These two roles need regulation in order to happen. In metabolic pathways, the enzymes that catalyze irreversible reactions may be the sites of control. In glycolysis the reactions catalyzed by hexokinase, phosphofructokinase and pyruvate kinase are virtually irreversible and therefore are expected to have regulatory and catalytic roles. These enzymes become more or less active in the response to the reversible binding of allosteric effectors. The amount of the enzymes also vary by the regulation of transcription to meet metabolic needs. Glycolysis in muscle is regulated to meet the need of atp. The primary control of glycolysis in muscles is the energy charge of the cell (the ratio of atp to amp). Phosphofructokinase: most important control site in the mammalian glycolytic pathway. Atp binds to a site disti(cid:374)ct fro(cid:373) the catalytic site, loweri(cid:374)g e(cid:374)zy(cid:373)e"s affi(cid:374)ity to fructose 6-phosphate.