BIOCHEM 3G03 Chapter Notes - Chapter 6: Coagulation, Hydrogen Bond, Fumarase
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In 1894, emil fischer proposed that a substrate molecule fits into the enzyme active site like a key in a lock. In order to accelerate rate of chemical reaction like peptide bond hydrolysis: increase the temperature (not very practical as speeds up all the rxns. Synthesized in pancreas and secreted in small intestine. One of the first enzymes to be crystalized. 241 a. a. residues form a compact two-domain structure (fig. Speeds up the rxn by 1011 orders of magnitude. Catalyzes the hydrolysis of peptide bond following phe, trp or tyr. Can also catalyze the hydrolysis of other amide and ester bonds. Pyruvate decarboxylase catalyzes the removal of co2 grp from pyruvate. 6-2 the chemistry of catalysis is the activation energy: g, a. . c is the transition state species (very shortlived: the height of the activation energy barrier determines the rate of a rxn. The higher the barrier, the slower the rxn.