BIOLOGY 2F03 Chapter 9-10: Side effects

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20 May 2018

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1. Side effects of stem cell transplant

• Acute/chronic toxicity of chemo = problems seen with the table above

• Acute neutropenia = infections (bacterial and fungal)

• Effects of immunosuppression =

o Chronic/late infections (pneumococcus, PCP, CMV)

o Acute GvHD (skin, gut liver)

▪ Prevent/treat with immunosuppressive (cyclosporine, tacrolimus, rapamicin, MMF,

CAMPATH) and corticosteroids

o Chronic GvHD (presents like scleroderma; skin, gut, liver lungs)

▪ Prevent/treat with immunosuppressive (cyclosporine, tacrolimus, rapamicin, MMF,

CAMPATH) and corticosteroids

• Long term complications

o Endocrinopathy (thyroid, adrenals, growth retardation)

o Infertility

o Cataracts

o Pulmonary dysfunction

o T-AML

2.27 - LEUKAEMIA - PAST,PRESENT & FUTURE

Cml

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