BIOLOGY 2F03 Chapter 9-10: Sporadic
20 May 2018
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Sporadic (non-endemic) Burkitts
• The same translocations are seen but the exact breakpoints are different from what is seen in
endemic burkitts
o EBV might be the key difference in mediating this
• Soradic is only associated with EBv in 10% of caes
• Affects abdominal organs (ovaries, caecum0 and breasts
HCV in lymphoma
• The importance of HCV in lymphoma seems to vary by country
• It causes monoclonal cryoglobulinaemia which leads to tissue necrosis
o Associated with SLVL, MALt lymphoma of salviares, DLBCL
• Patients with splenic marginal zone lymphoma appear to regress when HCV infection is treated
1. Role of auto-immune and other non-infective diseases in lymphoma etiology
• Principle is the same with inefctions - antigenic stimulation of host lymphocytes = chronic
proliferation
• Autoimmune diseases seem to give an increased incidence of Hodgkin lymphoma
o Sjogrens increases risk 6 fold (marginal zone, DLBCL, FL)
o SLE increases risk of DLBCL and Marginal Zone Lymphoma 3 fold
o Psoriasis and coeliac assoacited with T cell lymphoma
• Coeliac gives a high grade lymphoma of T mucosal lymphocytes
o i.e. the lymphoma arises in a T cell subset which is different to that which mediates the
autoimmune disease
o Incidence is increased 80x in people are left undiagnosed/untreated
• The autoimmune lymphoproliferative syndrome (ALPS)is a chronic polyclonal disorder resulting from
mutations that lead to failure of apoptosis
o Increased incidence of B NHL & HL as well as autoimmune diseases
