BIOLOGY 3UU3 Chapter Notes - Chapter 2: Pseudogene, Paraxial Mesoderm, Pitx1
13 Apr 2017
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Evolution at two levels: on genes and form [andrew chong] Classic paper evolution at two levels in humans and chimpanzees (king and wilson) (cid:120) concluded that the small degree of molecular divergence could not account for the anatomical/behavioural differences between chimps and humans (cid:120) It is therefore what controls the genes and not the protein sequences themselves that must change to account for this difference (cid:120) why was it a milestone? (cid:120) 1. First comparison of a large set of proteins between 2 close species (cid:198) comparative genomics (cid:120) 2. Used molecular data to understand the evolution of form (cid:198) evolutionary developmental biology (cid:120) 3. A brief history of regulatory thinking (cid:120) susumu ohno"s book: evolution by gene duplication, most important. Alternative protein isoform expression (cid:131) all increase the sources of variation while minimizing the pleiotropy associated with the evolution of coding sequences.
