HTHSCI 2F03 Chapter Notes - Chapter 6: Hbsag, Cirrhosis, Hepa
26 Dec 2020
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Viral hepatitis and hcc: worldwide = 625000 case per year -2002, 5th commonest in the world, highest in w. africa / e. asia > southern europe > northern europe. Hepatitis b and hcc: neonatal infection is more likely to cause chronic infection (95-100%) c. f. >10cml: hbsag can be derived from mature virions and defective particles, not just actively replicating infected cells (unlike hepb dna, reveal study showed it to correlate with hcc risk useful in inactive carriers with low. Hepb dna: genotype c (and b and f) may be associated with increased risk of hcc, gentyope b affects yunounger non-cirrhotic patient c. f. genotype c. Pathogenesis direct viral effect: hbv dna integrates within the chromosomes of infected hepatocytes. Duck hep b (dhbv) lacks an equivalent to hbx and doesn"t cause hcc: hbv mutants emerge due to errors in reverse transcription and anti-viral therapy: Dual mutations in basal core promoter (bcp): has or of 10. 6 for hcc progression c. f. inactive carriers.
