HTHSCI 2H03 Chapter Notes - Chapter 4: Lipid Bilayer, Electrochemical Gradient, Pharmacokinetics
13 Sep 2016
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Pharmacokinetics- the study of drug movement throughout the body: how body handles medications. The processes of pharmacokinetics are grouped into 4 categories: absorption, distribution, metabolism and excretion. The movement of a substance from its site of administration, across body membranes, to circulating fluids. 1: across membranes that that line gi or resp. tract. Most drugs must be absorbed to produce an affect. Absorption- primary factor determining the length of time it takes a drug to produce its effect ex. Drugs in elixir or syrup formulations are absorbed faster than tablets or capsules. Higher doses= absorbed faster & rapid onset compared to low concentrations. Digestive motility, exposure to enzymes in the digestive tract, blood flow to the site of drug administration. Drug-drug or food-drug interactions may influence absorption: ex. Administrating tetracyclines with food or drugs containing calcium, iron or magnesium can signif. Delay absorption: high fat meals= slow stomach motility & delay absorption or oral meds.
