KINESIOL 1Y03 Chapter Notes - Chapter 19.17: Chloramphenicol, Blood Transfusion, Isoniazid
20 Sep 2017
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Etiology infection; malignancy; inflammatory and rheumatologic disease; chronic renal and liver disease; endocrine disorders (e. g. diabetes mellitus, hypothyroidism, hypogonadism, hypopituitarism) Rbc production: may have elevation in acute phase reactants (esr, crp, fibrinogen, bone marrow, normal or increased iron stores in bone marrow, decreased or absent staining for iron in erythroid precursors. Treatment resolves if underlying disease is treated: only treat patients who can benefit from a higher hemoglobin level erythropoietin may normalize the hemoglobin value (dose of erythropoietin required is higher than dose required for patients with renal disease) Lead poisoning: l: lead lines on gingivae and epiphyses of long bones on x-ray, e: encephalopathy and erythrocyte basophilic stippling, a: abdominal colic and microcytic anemia (sideroblastic, d: drops --> wrist and foot drop. Dimercaprol and edta as first line of treatment. Definition: defects in the heme biosynthesis in erythroid precursors, uncommon compared to iron deficiency anemia or anemia of chronic disease. Sideroblasts erythrocytes with fe-containing (basophilic) granules in the cytoplasm.
