LIFESCI 2C03 Chapter 6: LS2CC3_CH6 notes
16 Feb 2016
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Glutamate is a nonessential amino acid and doesn"t cross blood-brain barrier therefore must be synthesized in neurons from local precursors: precursor glutamine taken up into presynaptic terminals by sat2, metabolized to glutamate by the glutaminase. 2ii. glucose metabolized by neurons can also synthesize glu: glu packaged into vesicles by vglut (at least 3 different vglut, once released, glu taken up form the cleft by na dependent co-transporters (5), Ampa receptors, nmda receptors and kainate receptors -> glutamate-gated cation channels allow passage of na and k; therefore, all these receptors produce excitatory postsynaptic responses. Most central synapses -> ampa and nmda receptors antagonist that block the two receptors revealed that epscs by nmda receptor is slower and last longer than ampa receptors. Nmda - glun2 subunits bind glu, glun1 and 3 bind glycine. typically composed of two gllun1 and two glun3 (glun3 sometimes replaces two. Gaba a/c ionotropic receptors three types of postsynaptic receptros called gaba a-c.
