PSYCH 2NF3 Chapter Notes - Chapter chap 28.5: Gaba Receptor Antagonist, Nucleus Accumbens, Bicuculline
14 Apr 2018
School
Department
Course
Professor
Document Summary
Opens cl channel, allowing cl to enter the cell to hyperpolarize the membrane. Sedative-hypnotic drugs known to enhance the effects of gaba by binding to their modulatory sites on the receptor complex. Alcohol modulates gaba function both directly via gabaa receptors and indirectly by stimulating gaba release. Picro toxin (blocks the cl channel) and bicuculline (competes with gaba for its receptor) antagonize both the hyperpolarization and some of the behavioural effects of alcohol. This suggests the both cl conductance and gaba binding to the receptor are necessary for the effects of alcohol to occur. Manipulations that increase gaba also increase alcohol-induced behavioural effects. Lines of mice bred for their sensitivity to some of the behavioral effects of alcohol show a relationship between the ability of ethanol to increase gaba- induced cl entry and the intensity of their response to alcohol.
