BIOL 116 Chapter Notes - Chapter 11, pg. 212-225: Cleavage Furrow, Centromere, Metaphase

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Biology 116: cell cycle and mitosis, chapter 11-11. 3 (learning outcomes) S, or synthesis, phase is when the dna is made and chromosomes are replicated: describe the roles of condensins, cohesins and lamins. Cohesins: ring-shaped protein encircle 2 sister chromatids at the centrosome area. Condensins: ring-shaped proteins consisting of 3 subunits that form loops on dna and condenses chromosomes to prepare for cell division. Nuclear lamins: intermediate filaments responsible for the breakdown and regeneration of a cell"s nuclear envelope before/after mitosis: describe, in detail, the processes occurring at each stage of mitosis. Prometaphase: nuclear envelope disintegrates and nucleolus temporarily disappears, kinetochore microtubules from each centrosome connect to 1 sister chromatid of each chromosomes (occurs at the kinetochore) Metaphase: centrosomes are found at opposite poles and mitotic spindle is formed, kinetochore microtubules bring the chromosomes to the metaphase plate (middle) and begin pulling them to opposite poles.

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