BCHM 316 Chapter Notes - Chapter **15.1: Skeletal Muscle, Tryptophan, Pyruvic Acid

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6 May 2018

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1. Pyruvate + HCO3- + ATP → oxaloacetate + ADP + Pi ; pyruvate

carboxylase (irreversible)

Liver, kidney

In order to form oxaloacetate from pyruvate, you add a carboxyl group

2. PEP ← → oxaloacetate ; PEP carboxykinase, PEP carboxylase

a. PEP + CO2 + GDP ⇒ oxaloacetate + GTP ; PEP carboxykinase

i. Heart, skeletal muscle

b. PEP + HCO3- ⇒ oxaloacetate + Pi ; PEP carboxylase

i. Higher plants, yeast, bacteria

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