EPID 301 Chapter Notes - Chapter 16: Prospective Cohort Study, Randomized Controlled Trial, Clinical Trial
11 Jul 2018
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A case-control study situated within a prospective cohort study. Whenever a case occurs, a control can be selected from among the cohort members who do not have the disease at that point in time (the risk set), providing a firm procedure for control selection. The exposure variable at issue have not been measured at the time of selection into the prospective cohort study. Can obtain extra exposure measurements by assessing exposure in the case group and in a sample of the non-case group (controls) Make selection of cases and controls easier, because the cohort is being actively followed and is presumably strongly engaged in research. Easier to ensure that cases are incident cases, because of close follow-up in the host study (greater clarity of the temporal relationship between exposure and disease) General definition: nested a case-control study within their cohort. Have a backward logical direction of inquiry. Begins with identification of a series of cases and then assess exposure.
