PSYC 370 Chapter Notes - Chapter 18: Venlafaxine, Haloperidol, Imipramine
Document Summary
Delusions, hallucinations, inappropriate affect, odd behaviour (lack of personal hygiene, difficulty performing daily tasks, talking in rhymes, catatonia), incoherent speech or thought (echolalia, illogical thinking, peculiar associations, belief in supernatural forces: negative symptoms: a reduction or loss of normal function. Dopamine theory of schizophrenia: theory that schizophrenia caused by too much dopamine and that antipsychotic drugs reduce symptoms by reducing dopamine, both reserpine & chlorpromazine antagonize transmission at dopamine synapses (cid:224) reserpine depletes brain of dopamine, chlorpromazine binds to dopamine receptors (receptor blocker). Note: with chlorpromazine, brain senses that dopamine isn"t binding and pumps out more dopamine, so levels remain the same with or without the drug: new theory: rather than high levels of dopamine, the main factor in schizophrenia = high levels of activity at dopamine receptors, haloperidol: a strong antischizophrenic drug with a relatively low affinity for dopamine receptors.
