PAT 20A/B Chapter Notes - Chapter N/A: American Diabetes Association, Aplastic Anemia, Guanethidine

• School: Ryerson University
• Department: Pathotherapeutics
• Course: PAT 20A/B
• Professor: Audrey Kenmir

Document Summary

(2)pat20 winter week 3-4 drug classifications (diabetes mellitus: anti-diabetics, insulin *metabolic agent* (anti-hyperglycemia) Insulin drugs: r- insulin lispro (humalog), s- regular insulin (humulin-r), i- nph: neutral protamine hagedone (novolin-n), l- insulin gargine (lantus), premixed regular insulin (humulin-r and nph 30/70) Action: insulin lowers blood glucose by stimulating glucose uptake in skeletal muscle and fat, inhibiting hepatic glucose production, lipolysis and proteolysis and enhances protein synthesis. Uses: control of hyperglycemia in patients with type 1 or type 2 diabetes mellitus, treats of diabetic ketoacidosis, patients requiring temporary insulin therapy during pregnancy, treats hyperkalemia (regular insulin only). Pharmacokinetics (rapid, short, intermediate & long acting insulin): Onset- r: less than 0. 5 hr; 30-60 min; i: 1-2 hrs; l: 3-4 hrs. Peak- r: 0. 5-1. 5 hrs; s: 2-4 hrs; i: 4-12 hrs; l: none. Duration- r: less than 8 hrs; s: 5-7 hrs; i: 18-24 hrs; l: 24 hrs. Derm: localized urticarial lesions (usually disappear), lipodystrophy of subcutaneous fat, pruritus.