BIOM 3090 Chapter Notes - Chapter CNS: Amyloid, Panic Disorder, Depressant

• School: University of Guelph
• Department: Biomedical Sciences
• Course: BIOM 3090
• Professor: Elizabeth Campbell

Document Summary

Interneurons: communicate within the same brain region: projection neurons: axons project from one brain region to another, neurons organized into circuits, classification of cns transmitters, 1. Interneurons associated with motor control: projection neurons associated with learning, memory, and cognition, 3. Drug induced: reversible, by antipsychotic drugs which block dopamine receptors. Irreversible: synthesis of mptp, destroys dopaminergic neurons in substantia, pathophysiology and treatment nigra, movement is controlled by 2 pathways in the basal ganglia, 1. Direct pathway: enables movement, dopamine stimulates this pathway (d1: 2. Indirect pathway: inhibits movement, dopamine inhibits this pathway (d2: degermation of dopaminergic neurons reduces activity of the direct pathway and enhances activity of the indirect pathway, ach releasing interneurons also modulate the output of the striatum. In pd, there is an imbalance between da and ach: therapeutic strategies, degeneration of dopaminergic neurons cannot be reversed, drugs are used to correct the imbalance of dopamine and ach activity in the basal ganglia, drugs used.