MBG 1000 Chapter Notes - Chapter 6: Paramesonephric Duct, Heterogametic Sex, Y Chromosome

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The human female has two x chromosomes and a male has one x and one y. It includes the palindromes and sequences similar to sequences on the x chromosome. Activation of sry starts gene action that causes testes to develop. Anti-mullerian hormone stops the development of female structures and testosterone stimulates development of male internal structures and directs development of external structures. In several disorders, chromosomal, gonadal, and/or phenotypic sex are inconsistent. Sexual identity includes sex chromosome makeup; gonadal specialization; phenotype (reproductive structures); and gender identity. The human male is the heterogametic sex, with an x and a y chromosome. The female, with two y chromosomes, is the homogametic sex. The human y chromosome includes two pseudo-autosomal regions and a large, male- specific region that does not recombine. Y-linked genes may correspond to x-linked genes, be similar to them, or be unique. Palindromic dna sequences or inverted repeats can promote gene loss on the y.

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