MICR 3230 Chapter Notes - Chapter 8: Hydrogen Bond, Phagocytosis, Cell C
9 Nov 2016
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Chapter 8: the major histo(cid:272)o(cid:373)pati(cid:271)ilit(cid:455) co(cid:373)ple(cid:454) a(cid:374)d a(cid:374)tige(cid:374) prese(cid:374)tatio(cid:374) Recall: bcr"s (ig"s) can recognize an ag alone. Tcr"s recognize pieces of ag that are positioned on the surface of other cells. Ag pieces held within the binding groove of a cell surface protein called the major histocompatibility complex (mhc) molecule, encoded by a cluster of genes collectively called the mhc locus. Mhc molecules decide which fragments of a foreign ag will be seen by t cells. Mhc got its name from the fact that the genes in this region encode proteins that determine whether a tissue transplanted between two individuals will be accepted or rejected. Work of benacerraf, dausset, and snell helped to characterize the functions controlled by mhc, specifically, organ transplant fate and the immune responses to antigen. Many alleles of most mhc genes, and the specific alleles one inherits play a significant role in susceptibility to disease, incl. development of autoimmunity.
