BIOL 200 Chapter Notes - Chapter 4: Mannose, Oligosaccharide, Secretion
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Overview: three semi-independent pathways: secretory pathway (exocytosis) E golgi (cid:894)secretor(cid:455) vesicles(cid:895) cell e(cid:454)terior. Proteins proceed by vesicle transport from golgi to cell surface. Vesicles fuse with plasma membrane releasing the proteins: lysosomal pathway. E golgi late e(cid:374)doso(cid:373)e l(cid:455)soso(cid:373)e. Proceed through er and golgi, then to late endosomes by vesicle transport: endocytic pathway. Cell e(cid:454)terior earl(cid:455) e(cid:374)doso(cid:373)e late e(cid:374)doso(cid:373)e. Proteins outside the cell interact with receptors in the plasma membrane. Moved to early endosomes where receptors are removed and recycled to plasma membrane. Proteins are moved to late endosomes and lysosomes (where digestion occurs) Both secretory and lysosomal pathway involve production of proteins. Proteins are transferred to the lumen of er and proceed through the golgi apparatus. Flow of material in golgi: cis to trans. Proteins are sorted as they move along (based on combination of chemical features) Increase in acidity inside golgi from cis to trans. 2 main destinations: extracellular space/cell surface and lysosomes.
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