PCTH 201 Chapter Notes - Chapter 18: Cell Wall, Cell Envelope, Dna Replication
22 Nov 2017
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Antibacterials more toxic to the bacteria e. g. bleach, hcl. Do(cid:374)"t (cid:374)e(cid:272)essaril(cid:455) (cid:374)eed to kill the (cid:271)a(cid:272)teria. Back when antibiotics have not been discovered something simple like paper cut or stepping on a nail could have been a life or death situation. Took ~14 years until penicillin was used more commonly. Goal: target bacteria without harming our own cells (selective-targeting) There are more bacterial cells than human cells. Bacteria exploit differences between mammalian vs. bacterial cell physiology/structure. Processes & enzymes differ but both replicate dna in the same way. Cell envelope: impacts antibiotic access & selectivity. Inhibition of: cell wall synthesis, protein production, dna replication, nucleotide production. Cell wall is important because it helps maintain osmotic forces and control passage of material in/out of the cell. When the pg sheet is not linked together, cell wall can fall apart readily. More effective against gm +ve more pg to interfere with and no om barrier.
