ANP 1107 Chapter Notes - Chapter 16, 24: Brown Adipose Tissue, Ghrelin, Proopiomelanocortin

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Regulation of metabolism and body temperature ch 24. Insulin activity deficient or absent; insulin has no back-up hormone: blood glucose is high after a meal but cells are unable to utilize glucose for energy production. I(cid:374) a(cid:271)se(cid:374)(cid:272)e of a(cid:374) i(cid:374)suli(cid:374) sig(cid:374)al, glu(cid:272)ose (cid:272)a(cid:374)(cid:859)t e(cid:374)te(cid:396) (cid:272)ells body responds by mobilizing fats: when hyperglycemia is excessive, person feels nauseated. Fats are mobilized when sugars (cid:272)a(cid:374)(cid:859)t (cid:271)e used as (cid:272)ellula(cid:396) fuel = high fatt(cid:455) a(cid:272)id le(cid:448)els i(cid:374) (cid:271)lood. If this becomes too severe it can disrupt processes including cns, heart activity and o2 transport, leading to coma and death: acetone in breath is a sign of ketosis ketone body that can be produced from acetyl-coa. Metabolic role of liver conducts over 500 metabolic fns (one of most biochemically complex organs in the body) processes nearly every class of nutrients and plays a major role in regulations of plasma cholesterol levels.

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