BIO 1140 Chapter Notes - Chapter 5: Prostaglandin, Exocytosis, Paracrine Signalling

• School: University of Ottawa
• Department: Biology
• Course: BIO 1140
• Professor: Caroline Petit- Turcotte

Document Summary

Gpcr (camp and ip3 pathways: des(cid:272)ri(cid:271)e i(cid:374) detail a(cid:374) e(cid:454)a(cid:373)ple of a (cid:272)ellular respo(cid:374)se with its sig(cid:374)al tra(cid:374)sdu(cid:272)tio(cid:374) (cid:272)as(cid:272)ade, re(cid:272)og(cid:374)ize a(cid:374)d des(cid:272)ri(cid:271)e the (cid:373)e(cid:272)ha(cid:374)is(cid:373)s (cid:894)6(cid:895) that (cid:272)a(cid:374) terminate a cellular response. 5. 7 signal transduction links signals with downstream cell responses. Receptors are specific and are found on outer and inner membranes (er, mito: transduction. Receptor triggers cell changes to cause response (signaling cascade: response. Hydrophilic bind to receptors outside membrane, changes shape of cytoplasmic side of the receptor. Travel through membrane with channel, binds to a receptor within the cell. Can bind to receptors on nucleoplasm, receptor then binds to a control sequence. This leads to transcription changed, and protein synthesis. The cell response is based on which gene is transcribed. Experiments show: signal molecules have no response when in the cytoplasm, mimics of signal proteins can either trigger or block cellular response when they bind to recognition site.