BIOC39H3 Chapter Notes - Chapter 2: The Immediate, Thioester, Clostridium
Document Summary
Chapter 2 innate immunity: the immediate response to infection. The immune system has 3 lines of defense. Innate immunity; ready for action at all times and function from the very beginning of an infection. 2-1 physical barriers colonized by commensal microorganisms protect against infection by pathogens. 2-2 intracellular and extracellular pathogens require different types of immune response. Extracellular infections; pathogens that live and replicate in the spaces between human cells. Intracellular infections; pathogens that replicate inside human cells to produce. Extracellular pathogens are accessible to soluble, secreted molecules of the immune system, whereas intracellular pathogens are not. The strategy used to attack intracellular pathogens is to kill the human cells in which the pathogens are living. This sa(cid:272)rifi(cid:272)e i(cid:374)terferes (cid:449)ith the pathoge(cid:374)"s life (cid:272)(cid:455)(cid:272)le a(cid:374)d e(cid:454)poses a(cid:374)(cid:455) pathoge(cid:374)s released fro(cid:373) the dead cells to the soluble molecules of the immune system. Many pathogens have life cycles that involve both extracellular and intracellular forms.
