HLTB22H3 Chapter Notes - Chapter 0: Rna Splicing, Crispr, Royal Naval Air Service
Document Summary
Francis crick-> proposed his theory for the central dogma of molecular biology, it described how genetic information flows from dna to rna to protein. Proteins are the end product of the gene, viewed as the functional units of the cell. Dna is considered to be a stable molecule that stores genetic information. Rna is considered as the temporary message between dna and protein. However this model did not include ncrnas. More than 75% of the human genome is in fact transcribed into rna. Rna serves as a primer for dna synthesis and as a template molecule for revers transcription of telomerase. Rnas can link with proteins and modify their activity or recruit them to other nucleic acids through complementary base pairing. We are discovering that most noncoding sequences can be transcribed and even display important anticancer functions. Catalytic activity of rnas: ribozymes and the origin of life. Rnas can be catalysts due to rnas can form complex secondary structures.
