BIO130H1 Chapter Notes - Chapter 12.2: Cytoskeleton, Progeria, Nucleoplasm
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BIO130H1 Full Course Notes
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12. 2: structure of the nuclear envelope: large genomes are packed into sna protein complexes called chromatin. But dna in prokaryotes is not packaged into chromatin. Binding proteins (rna polymerase, repressors etc. ) can directly bind to binding sites. Consists of two cellular membranes parallel to one another. Contains 60 transmembrane proteins, one of which connects the outer nuclear membrane with elements of the cytoskeleton. Inner and outer membrane are fused together at some parts which form pores that contain complex assemblies of proteins. Outer membrane is studded with ribosomes and is continuous with the membrane of the rough er. Serves as a site for attachment for chromatin fibres. Composed of p. p. called lamins: mutations in one of the lamin genes ( lmna ) are responsible for a number of diverse human diseases, including a rare form of muscular dystrophy (called.
