BIO130H1 Chapter Notes - Chapter 18: Nanopore, Peptide, Chromosome
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BIO130H1 Full Course Notes
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The first of these new strategies is referred to as massively parallel sequencing and has dominated genomic sequencing efforts for the past several years: unlike the sequencing steps of the original human genome. Project, massively parallel sequencing technologies do not require that pieces of the genome be cloned in yeast or bacteria and each is subsequently amplified to form a huge population. Instead, fragments are prepared directly from the whole genome. The short segments being synthesized (cid:4666)called (cid:498)reads(cid:499)(cid:4667) do become. Consequently, these dna sequencing technologies are best suited for studying individual genomes from a species, such as the human species, where researchers already possess a reference genome into which a given dna fragment can be placed. Another problem with the use of massively parallel sequencers is that the data cannot be sorted into a person"s separate maternal and paternal haploid genomes, or their haplotypes.
