BIO130H1 Chapter : pg. 1150-1155.docx
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BIO130H1 Full Course Notes
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Document Summary
Epithelia has two sides: basal and apical side. Tight junction form a seal between cells and a fence between membrane domains. Occluding junctions found in the epithelia are called tight junctions. Absorption of materials begins at the apical side through channels. Then the nutrients is delivered through the blood by entering the basal side. Tight junctions separate the material from lumen to extracellular matrix. Tight junctions are made of sealing strands: two interacting plasma membranes proteins. The protein claudin and occudin are used to form the sealing strands. Claudin 1 is important to maintain the storage of water; without it skin cells would dry up. Scaffold proteins in junctional complexes play a key part in the control of cell.
