pg. 1150-1155.docx

3 views1 pages
10 Apr 2012
School
Department
Course
Professor
Pg.1150-1155
Tight Junctions and the Organization of Epithelia
Epithelia has two sides: basal and apical side
The epithelia is structurally polarized
Tight Junction Form a Seal Between Cells and a Fence Between Membrane Domains
Occluding junctions found in the epithelia are called tight junctions
Absorption of materials begins at the apical side through channels
Then the nutrients is delivered through the blood by entering the basal side
Tight junctions separate the material from lumen to extracellular matrix
Tight junctions are made of sealing strands: two interacting plasma
membranes proteins
The protein claudin and occudin are used to form the sealing strands
Claudin 1 is important to maintain the storage of water; without it skin cells
would dry up
Claudin has 24 members
Scaffold Proteins in Junctional Complexes Play a Key Part in the Control of Cell
Proliferation
Form a junctional Complex: tight junctions, adherens junction and
desmosomal junctions
Unlock document

This preview shows half of the first page of the document.
Unlock all 1 pages and 3 million more documents.

Already have an account? Log in

Get OneClass Notes+

Unlimited access to class notes and textbook notes.

YearlyBest Value
75% OFF
$8 USD/m
Monthly
$30 USD/m
You will be charged $96 USD upfront and auto renewed at the end of each cycle. You may cancel anytime under Payment Settings. For more information, see our Terms and Privacy.
Payments are encrypted using 256-bit SSL. Powered by Stripe.