pg. 1150-1155.docx

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10 Apr 2012
Tight Junctions and the Organization of Epithelia
Epithelia has two sides: basal and apical side
The epithelia is structurally polarized
Tight Junction Form a Seal Between Cells and a Fence Between Membrane Domains
Occluding junctions found in the epithelia are called tight junctions
Absorption of materials begins at the apical side through channels
Then the nutrients is delivered through the blood by entering the basal side
Tight junctions separate the material from lumen to extracellular matrix
Tight junctions are made of sealing strands: two interacting plasma
membranes proteins
The protein claudin and occudin are used to form the sealing strands
Claudin 1 is important to maintain the storage of water; without it skin cells
would dry up
Claudin has 24 members
Scaffold Proteins in Junctional Complexes Play a Key Part in the Control of Cell
Form a junctional Complex: tight junctions, adherens junction and
desmosomal junctions
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