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BIO130H1 Chapter : Pg.1131-1135.docx

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10 Apr 2012

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BIO130H1 Full Course Notes

BIO130H1 Full Course Notes

Document Summary

Cell junctions, cell adhesions and the extracellular matrix. Cell-cell adhesion: tie the cytoplasm of many cells together. Connective tissue: (bone or tendon) are cells distributed in the extracellular matrix. Epithelial tissues: line the gut or the epidermal covering of the skin; made up of layers called the epithelia. Adherens junctions anchor sites for actin filaments. Desmosome junctions are anchor sites for intermediate filament. Hemidesmosome: anchor intermediate filaments to extracellular matrix. Each of the 4 types of protein play a role in transmembrane adhesion proteins. These proteins can be divided into two groups. Caderins mediate ca2+-dependent cell-cell adhesion in all animals. The cadherin superfamily in vertebrates includes hundreds of different proteins,

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Related Questions

Match the following choices to the statements.

1) Formed by proteins that create tunnels between cells

a) Adhesion Belts

b) none are correct

c) desmosomes

d) gap junctions

e) tight junctions

2) A site of linkage between the extracellular matrix and the cytoskeleton

a) Adhesion Belts

b) none are correct

c) desmosomes

d) gap junctions

e) tight junctions

3) A site of linkage between the actin cytoskeleton of two adjacent cells

a) Adhesion Belts

b) none are correct

c) desmosomes

d) gap junctions

e) tight junctions

4) Rely on intermediate filaments to connect cells to an adjacent cell

a) Adhesion Belts

b) none are correct

c) desmosomes

d) gap junctions

e) tight junctions

5) Are non-functional in patients with a genetic disorder known as Pemphigus vulgaris

a) Adhesion Belts

b) none are correct

c) desmosomes

d) gap junctions

e) tight junctions

6) Are abundant in tissues that experience high mechanical stress (e.g., heart muscle)

a) Adhesion Belts

b) none are correct

c) desmosomes

d) gap junctions

e) tight junctions

Describe the five variable influences inherent to cell culture.

Name the four major classes of transmembrane cell adhesion proteins.

Which are mainly responsible for cell-cell adhesion?

Which are mainly responsible for cell-matrix adhesion?

What specifically is responsible for mediating the anchorage of cells in culture to the substrate?

Describe six different molecules that compose the extracellular matrix.

Explain cell motility. Include lamellipodia, actin, plasma membrane, and c

We have considered several different kinds of cell-cell junctions found in epithelial cells. For the two types here, tight and adherens junctions, select the correct properties or functions associated with it:(A) Keeps the sheet anchored: mediates interaction of the cells with the basal lamina, or underlying extracellular matrix. (B) Brings the plasma membrane of adjacent cells into such close apposition that even small molecules can

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