CHM247H1 Chapter 20: chm247 all about Chapter 20.pdf
Document Summary
Similar electron distribution for these two functional groups: carbon has three bonds to a more electronegative atom (o or n, at least one bond of those three is a bond. Carboxylic acid has one and one bond to an o; one bond to the other o. Nitrile has one and two bonds to an n. Both are aromatose inhibitors; aromatose is the enzyme responsible for estrogen synthesis, so these are anti-tumour drugs for estrogen-stimulated tumours: also found in contraceptives, hence, hormone replacement therapies can actually cause cancer . Replace -e of the parent alkane chain with -oic acid : do not need to specify location of the carboxyl group in the chain because it is a terminal functional group and is therefore always located at c1. Carboxyl group (-cooh) is the highest priority functional group in all the organic groups we cover in this course; hence, any compound with a carboxyl group will be named as a carboxylic acid.
